Accession Number:

ADA399147

Title:

Oral Contraceptives Use by Young Women Reduces Peak Bone Mass

Descriptive Note:

Annual rept. 1 Sep 2000-31 Aug 2001

Corporate Author:

BOWMAN GRAY SCHOOL OF MEDICINE WINSTON-SALEM NC

Personal Author(s):

• Register, Thomas

Report Date:

2001-09-01

Pagination or Media Count:

20.0

Abstract:

The goal of these studies was to determine the role that hypoandrogenemia plays in the effects of oral contraceptives OC on bone metabolism and peak bone mass PBM in young female rats. Adolescentyoung adult Sprague-Dawley rats were treated with 1 placebo, 2 OC, 3 OC supplemented with an androgen methyltestosterone, or 4 an anti-androgen bicalutamide to determine the potential role that suppression of androgens plays on bone metabolism, bone architecture, and the attainment of PBM. Our specific aims were to determine 1 If oral contraceptive steroid OC treatment leads to decreased peak bone mass in young intact female rats. Findings OC use decreased the peak bone mass of young intact female rats. 2 If the addition of a non-aromatizable androgenic steroid to OCs prevents the detrimental effects of OC use on peak bone mass. Findings The non-aromatizable androgenic steroid did not prevent the adverse effects of OCs to the growing skeleton of young rats at the dose used. 3 If anti-androgen treatment mimics the effect of OC use on peak bone mass. Findings The anti-androgen used did not mimic the adverse effect of OCs on the growing skeleton of young rats.

Descriptors:

• *METABOLISM
• *ORAL INTAKE
• *BONES
• *CONTRACEPTION
• PEAK VALUES
• RATS
• ADVERSE CONDITIONS
• DOSAGE
• ARCHITECTURE
• PLACEBOS
• WOMEN
• ADULTS
• SUPPRESSION
• FEMALES
• SKELETON
• STEROIDS
• ANDROGENS

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE