Accession Number:

ADA399057

Title:

Discovery of a Novel Mammary Developmental and Cancer Genes Using Recessive ENU Mutagenesis

Descriptive Note:

Final rept. 1 Sep 2000-31 Aug 2001

Corporate Author:

GARVAN INST OF MEDICAL RESEARCH SYDNEY (AUSTRALIA)

Personal Author(s):

• Ormandy, Christopher J.

Report Date:

2001-09-01

Pagination or Media Count:

13.0

Abstract:

A screen of the first round of large scale mutagenesis has been completed. Six pedigrees with members harboring mammary tumors were identified. These pedigrees were recreated from genetic backups and are now being screened using mammary biopsy. Affected females will be used to establish stable breeding lines.

Descriptors:

• *MUTATIONS
• *GENES
• *MUTAGENS
• *GENETICS
• *BREAST CANCER
• NEOPLASMS
• CELLS(BIOLOGY)
• FEMALES
• MAMMARY GLANDS
• GENOME

Subject Categories:

• Genetic Engineering and Molecular Biology
• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE