Accession Number:

ADA399028

Title:

Characterization of Putative Homeostatic Molecules in Prostate Development and Androgen-Independent Prostate Cancer

Descriptive Note:

Annual rept. 1 Jan 2000-31 Dec 2001

Corporate Author:

TEXAS UNIV AT DALLAS SOUTHWESTERN MEDICAL CENTER

Personal Author(s):

• Hsieh, Jer-Tsong

Report Date:

2001-01-01

Pagination or Media Count:

71.0

Abstract:

Androgen-independent AI prostate cancer PCa is a life-threatening disease. No effective treatment is available for this disease because the biology of AIPCa is still unknown. It is known that AIPCa possesses many similar properties of the basal or stem cell in prostate. Therefore, in this project, we studied the signal pathways controlling growthdifferentiation of basal cells of prostate. We focused on two unique molecules, C-CAM1 and DOC-2, because both proteins often loss their expression on PCa and are a potent growth inhibitor. For C-CAM1, we analyzed the functional domain of C-CAM1 that modulates its tumor suppression function.

Descriptors:

• *PROSTATE CANCER
• MOLECULES
• PROTEINS
• CELLS(BIOLOGY)
• EPIDERMIS
• TYROSINE
• HOMEOSTASIS
• PROSTATE GLAND
• PHOSPHORYLATION
• ANDROGENS
• PHOSPHORUS TRANSFERASES

Subject Categories:

• Biochemistry
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE