Accession Number:

ADA398204

Title:

Cell-Cell Adhesion and Insulin-Like Growth Factor I Receptor in Breast Cancer

Descriptive Note:

Final rept. 15 Aug 1997-14 Aug 2001

Corporate Author:

THOMAS JEFFERSON UNIV PHILADELPHIA PA

Personal Author(s):

• Bartucci, Monica
• Surmacz, Ewa

Report Date:

2001-09-01

Pagination or Media Count:

75.0

Abstract:

This is a final report of the research carried out between 8151997 and 8142001. Our goal was to study the role of the insulin-like growth factor I receptor IGF-IR in breast cancer. The IGF-IR is a multifunctional tyrosine kinase that has been recently implicated in breast tumor development and progression. The IGF-IR is often overexpressed in estrogen receptor ER-positive breast tumors and this feature predicts enhanced tumor drug- and radio-resistance and cancer recurrence at the primary site. Our research demonstrated that the IGF-IR induces cell survival, growth and estrogen-independence in hormone-sensitive cells.

Descriptors:

• *BREAST CANCER
• EPITHELIUM
• ADHESION
• CELLS(BIOLOGY)
• MAMMARY GLANDS
• INSULIN
• TYROSINE
• ESTROGENS
• PHOSPHORUS TRANSFERASES
• METASTASIS

Subject Categories:

• Biochemistry
• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE