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Cell-Cell Adhesion and Insulin-Like Growth Factor I Receptor in Breast Cancer
Final rept. 15 Aug 1997-14 Aug 2001
THOMAS JEFFERSON UNIV PHILADELPHIA PA
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This is a final report of the research carried out between 8151997 and 8142001. Our goal was to study the role of the insulin-like growth factor I receptor IGF-IR in breast cancer. The IGF-IR is a multifunctional tyrosine kinase that has been recently implicated in breast tumor development and progression. The IGF-IR is often overexpressed in estrogen receptor ER-positive breast tumors and this feature predicts enhanced tumor drug- and radio-resistance and cancer recurrence at the primary site. Our research demonstrated that the IGF-IR induces cell survival, growth and estrogen-independence in hormone-sensitive cells.
APPROVED FOR PUBLIC RELEASE