Hereditary Breast Cancer: Mutations within BRCA1 and BRCA2 with Phenotypic Responses
Final rept. 1 Jul 1997-30 Jun 2001
CREIGHTON UNIV OMAHA NE
Pagination or Media Count:
Eighty-five hereditary breast ovarian cancer HBOC families are identified as having a BRCA1 or BRCA2 germline mutation. Five hundred and thirty eligible individuals were identified for the study. Three hundred and eighty-eight of these individuals provided permission to obtain slides and blocks on their breast cancer. We were not able to obtain 103 of these cases due to the slides and blocks being destroyed or the hospital did not respond to our requests. Slides and blocks have been collected on two hundred and eighty-five cases. Sixteen of these cases were ascertained from Dr. Narods center in Toronto, Canada. Two-hundred and seventeen are carriers of a BRCA1 mutation and 68 are BRCA2 carriers. Pathologic analysis has been completed on 187 cases, leaving 98 cases pending analysis. HE slides and DNA flow cytometry were completed for 280 cases. Ninety cases have been evaluated for estrogen receptor ER, progesterone receptor PR, and c-erbB-2. Histopathological analysis could not be completed this year by Dr. Marcus and Dr. Page, due to staffing conflicts. In summary of last years results when compared with non-hereditary breast cancers HBC, BRCA2 HBCs appear to be more similar to usual breast carcinomas. BRCA1 HBC appears to be the deviant phenotype.
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