Accession Number:

ADA394686

Title:

Evaluation of Drug and Vaccine Candidates in the Human Malaria/Aotus Monkey Model

Descriptive Note:

Final addendum rept. 1 May 1995-30 Sep 2001

Corporate Author:

PROMED TRADING S A MIAMI FL

Personal Author(s):

Report Date:

2001-10-01

Pagination or Media Count:

21.0

Abstract:

This report presents data On the evaluation of antimalarial drugs. Experimental drugs GJ-287 WR282650 BP20546 and GJ-QZ WR282651 BP20537 were non toxic when given to Aotus orally at 20 mgkg for three consecutive days and only transient changes on blood leukograms and liver enzyme ALT were detected. These drugs were not effective alone or in combination with Chloroquine when Aotus monkeys infected with Plasm odium falciparum FVO strain were treated for three consecutive days. Significant differences on Lymphocytes and Granulocytes counts were found between male and female Aotus when hematological and renal chemistry values of feral laboratory adapted Aotus monkeys were determined.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE