Role of a Novel Matrix-Degrading Metalloproteinase in Breast Cancer Invasion
Annual rept. 1 May 2000-30 Apr 2001
ARKANSAS UNIV FOR MEDICAL SCIENCES LITTLE ROCK
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The hypothesis of this proposal is that breast cancer cells are capable of breaking down the extracellular matrix barrier and this plays an important role in breast cancer invasion and metastasis. This study is based on our previous observation that breast cancer tissue expresses a meprin-like protein, which can be identified by immunostaining of breast cancer tissue using anti-meprin antibody. During the first year, our research was focused on the expression of meprin alpha in bacteria and raising antibody to the recombinant protein in order to have a tool for the identification of the meprin-like protein in tissues and extracted proteins. In addition, we performed immunohistology studies of human breast tumor and kidney tumor tissues, and produced data on experimental tumor growth with and without inhibition of meprin.
- Anatomy and Physiology
- Medicine and Medical Research