Accession Number:

ADA394344

Title:

Permanent Implantation Brachytherapy for Prostate Cancer Using a Mixture of Radionuclides with Different Half Lives

Descriptive Note:

Annual rept. 1 Mar 2000-28 Feb 2001

Corporate Author:

YALE UNIV NEW HAVEN CT SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

2001-03-01

Pagination or Media Count:

15.0

Abstract:

The project objective is to test whether the effectiveness of brachytherapy for prostate cancer can be improved by using a combination of short and long half life radionuclides simultaneously. Key research accomplishments in the past year are i a theoretical model based on incomplete repair of radiation damage at low dose rates was developed for addressing the questions raised in the project ii cell survival curves for both 125I and 103Pd were measured using monolayers of cells in a petri dish irradiated at low dose rates using 125I and 103Pd sources iii an afterloading seed applicator was designed and fabricated in order to produce a consistent dose distribution to irradiate tumors transplanted to different animals and to minimize the radiation exposure to personnel handling radioactive seeds. In summary, we have made considerable progress towards the development of a theoretical model for continuous low dose rate irradiation using a mixture of radionuclides. Relative biological effectiveness of 125I and 103Pd at low dose rates in vitro was determined. An applicator for in vivo irradiations was designed and fabricated. Animal care procedures during the long low dose rate irradiations were developed. We are now ready to launch in vivo experiments with radioactive sources.

Subject Categories:

  • Medicine and Medical Research
  • Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE