Molecular Epidemiology of Prostate Cancer
Annual rept. 1 Jan-31 Dec 2000
GEORGETOWN UNIV WASHINGTON DC
Pagination or Media Count:
The objective of this case-control study is to determine whether oxidative stress, specifically lipid peroxidation, is a risk factor for prostate cancer. Furthermore, the study will investigate with oxidative stress mediates the association between high dietary fat intake and prostate cancer risk. Specifically, the study will compare malondialdehyd MDA in serum, as a marker of lipid peroxidation, and deoxyguanosine malondialdehyde dG MDA in peripheral lymphocytes and prostate tumor as a marker of oxidative DNA damage. These associations will be adjusted by dietary measures of fat and antioxidant intake, as well as serum measures of specific fatty acids and antioxidants. Because redox cycling of androgens as recently been shown to be a source of reactive oxygen species, serum androge levels will also be correlated with MDA, dG-MDA, and risk. If an association between lipid peroxidation and prostate cancer risk is demonstrated, it could lead to new strategies for prevention especially chemoprevention and markers that could define men at high risk. This report covers patient accrual activities during Year 1, and preliminary analyses of MDA and antioxidants in serum. It also discusses changes to be implemented in Year 2.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research