Accession Number:

ADA394288

Title:

Synthesis, Conformational Analysis, and Biological Activity of Proposed Vitronectin Antagonists

Descriptive Note:

Annual summary rept. 1 Apr 2000-31 Mar 2001

Corporate Author:

KANSAS UNIV LAWRENCE

Personal Author(s):

Report Date:

2001-04-01

Pagination or Media Count:

32.0

Abstract:

This project concerned the synthesis of a series of peptidomimetics, eventually directed toward drugs that would interfere with angiogenesis and therefore act as potential anticancer agents. The peptidomimetics, based on the beta-turn motif, contained a dipeptide core, which maps onto the central two residues of the naturally occurring turn, and a linker portion. The linker is necessary to enforce the desired turn type and to provide room for a third amino acid side chain mimic. In the reporting period, a series of linkers based on phenylalanine was prepared and inserted into the cyclic peptidomimetics. Once prepared, the resulting macrocycles were shown to adopt predominantly type II or II turns, depending on the location of the phenylalanine side chain.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE