Novel Mechanisms by Which Estrogen Induces Antiapoptosis in Breast Cancer
Annual rept. 10 Jul 2001-9 Jul 2001
CALIFORNIA UNIV IRVINE
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We have investigated the mechanisms by which estrogen serves as a survival factor for breast cancer, during chemotherapy or irradiation treatment in-vitro. UV irradiation for one minute or four hour treatment with taxol results in substantial apoptosis of breast cancer cell lines. This is due to a c-jun N-terminal kinase activation, leading to an inactivating phosphorylation of Bcl2 and Bclx-L proteins, leading to caspase 9 activation and cell death. Estrogen blocks this proximally, at JNK activation. Independently, estrogen stimulates ERK MAP kinase activity which also contributes to cell survival. This was published in Molecular Endocrinology 1491434-47, 2000.
- Medicine and Medical Research