Elucidation of Pertussis Toxin-Sensitive Migration Signaling in Human Breast Cancer Cells
Annual summary rept. 1 May 2000-30 Apr 2001
NEVADA UNIV LAS VEGAS
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The long range goal of this laboratory is to identify integrin-associated signaling events that contribute to the constitutive migration of human breast cancer cells on the laminin extracellular matrix proteins. This project has shown that the heterotrimeric G-protein G alpha i3 may link integrin activation and migration of MCF-10A cells via a cAMP signaling pathway. The focus of the remaining work on this project is to identify how each integrin subtype which binds laminin-1 contributes to the regulation of this and other pro- migratory signaling pathways.
- Medicine and Medical Research