Accession Number:

ADA394243

Title:

Elucidation of Pertussis Toxin-Sensitive Migration Signaling in Human Breast Cancer Cells

Descriptive Note:

Annual summary rept. 1 May 2000-30 Apr 2001

Corporate Author:

NEVADA UNIV LAS VEGAS

Personal Author(s):

Report Date:

2001-05-01

Pagination or Media Count:

15.0

Abstract:

The long range goal of this laboratory is to identify integrin-associated signaling events that contribute to the constitutive migration of human breast cancer cells on the laminin extracellular matrix proteins. This project has shown that the heterotrimeric G-protein G alpha i3 may link integrin activation and migration of MCF-10A cells via a cAMP signaling pathway. The focus of the remaining work on this project is to identify how each integrin subtype which binds laminin-1 contributes to the regulation of this and other pro- migratory signaling pathways.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE