Characterization of Novel Breast Cancer Specific Gene, BCSG1, in Human Breast Cancer Progression
Annual summary rept. 1 Jul 1999-30 Jun 2000
LONG ISLAND JEWISH-HILLSIDE MEDICAL CENTER NEW HYDE PARK NY
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We recently identified and cloned a novel breast cancer-specific gene BCSG1 by direct differential cDNA sequencing. BCSG1 has a great sequence homology with Alzheimer disease AD-related neural protein synuclein, and thus was also named as synuclein gamma SNCG. We demonstrated that 1 SNCG expression was a stage-specific in human breast undetectable in normal or benign breast lesions, low level and partial expression in low grade ductal carcinoma in situ but extremely high level in advanced infiltrating breast cancer 2 SNCG expression in human breast cancer cells is dramatically suppressed by tumor growth inhibitor oncostatin M OM, a cytokine predominantly produced by activated T cells and macrophages and 3 overexpression of SNCG in breast cancer cells led to a significant increase in cell motility and invasiveness in vitro and a profound augmentation of metastasis in vivo. Our data suggest that the member of neural protein synucleins might have important functions outside the central nervous system and play a role in breast cancer progression.
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology
- Medicine and Medical Research