Accession Number:

ADA394196

Title:

Oncogenic Functions of cdK4 and cdK6

Descriptive Note:

Final rept. 1 Jul 1997-30 Jun 2000

Corporate Author:

HARVARD MEDICAL SCHOOL BOSTON MA

Personal Author(s):

Report Date:

2000-07-01

Pagination or Media Count:

22.0

Abstract:

The purpose of the research presented here is to investigate the pathways by which cdk4 and cdk6 stimulate unregulated cell division in cancer cells and the mechanism by which these kinases are differentially activated. Numerous reports have shown that increased expression and protein levels of cdk4 and cyclin D proteins are found in breast cancer, but cdk6 is preferentially activated in oral epithelial cancers. Results summarized here recapitulate these differences in cell culture systems, suggest novel mechanisms of regulation of cdk4 and cdk6 and further Support functional differences between these two kinases. A novel method for identifying proteins that differentially interact with the two kinases is also described and studies on several new interactors provide insight into specific potential regulators and substrates of these cdks.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE