Bin1, Apoptosis, and Prostate Cancer
Annual rept. 1 Aug 1999-31 Jan 2001
PENNSYLVANIA UNIV PHILADELPHIA WISTAR INST
Pagination or Media Count:
In this research project, we had proposed to investigate the utility of the Bin1 gene as a diagnostic andor prognostic marker in prostate malignancy and to perform proof-of-principle tests of its ability to induce apoptosis in androgen independent cancer cells. Bin1 encodes a set of adaptor proteins, the first of which was identified in our laboratory by virtue of its ability to interact with and inhibit the oncogenic properties of the Myc oncoprotein, which is frequently deregulated in prostate carcinoma. Work from our laboratory has suggested a tumor suppressor role for Bin 1, including a role in mediating p53-independent apoptosis by c-Myc in neoplastically transformed cells. A role in prostate cancer was prompted by the finding that the Bin1 gene mapped to the midsection of chromosome 2q, within a region that is deleted in 40 of metastatic prostate carcinomas. Preliminary data presented in the grant application supported the candidacy of Bin1 as a 2q tumor suppressor gene that is lost or altered during progression to androgen independence, when apoptotic responses are blunted.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research