Accession Number:

ADA394134

Title:

A Multileaf Collimator for Modulated Electron Radiation Therapy for Breast Cancer

Descriptive Note:

Annual rept. 1 Apr 2000-31 Mar 2001

Corporate Author:

STANFORD UNIV PALO ALTO CA

Personal Author(s):

Report Date:

2001-04-01

Pagination or Media Count:

61.0

Abstract:

In this project, we investigate a prototype electron multileaf collimator eMLC for energy- and intensity-modulated electron radiotherapy MERT for breast cancer to deliver dose distributions that closely match the target volume and minimize the dose to critical normal structures. We have worked on the following tasks 1 to design an eMLC using Monte Carlo simulations, 2 to manufacture an eMLC for MERT beam delivery, 3 to develop software tools for MERT beam delivery with an eMLC, and 4 to perform experimental evaluations of the prototype eMLC. During the first year research, we have established clinical criteria for MERT beam delivery, performed extensive Monte Carlo simulations of the eMLC materials and dimensions, evaluated the eMLC simulation based on the clinical criteria, and finalized the eMLC design based on our results. The results confirmed that an eMLC is superior to a conventional photon MLC and to electron cutouts for MERT beam delivery. It has better beam characteristics in terms of beam penumbra and better beam delivery efficiency. Since the principle investigator left Stanford University in Sept 2000 a replacement has been identified starting April 1 2001. Thus, the specific aim 2 scheduled for months 6 - 12 is postponed.

Subject Categories:

  • Medicine and Medical Research
  • Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE