Cell Surface Regulation of Matrix Metalloproteinases in Breast Cancer Cells
Annual rept. 1 Jul 1999-1 Jul 2000
WAYNE STATE UNIV DETROIT MI
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Metastasis is the major cause of death in breast cancer patients and is partly caused by the action of proteolytic enzymes that degrade extracellular matrix ECM. We have focused on the gelatinases, MMP-2 and MMP-9, two ECM-degrading enzymes that are members of the matrix metalloproteinase MMP family of proteases. The gelatinases are associated with the surface of breast cancer cells. MMP-2 surface binding plays a role in activation by MMT1-MMP, a membrane-bound MMP that is also expressed in breast cancer. MMP-2 activation is mediated by the action of TIMP-2, a metalloproteinase inhibitor.
- Medicine and Medical Research