Insulin and Breast Cancer Risk
Annual rept. 1 Jun 2000-31 May 2001
STATE UNIV OF NEW YORK AT BUFFALO AMHERST
Pagination or Media Count:
There is evidence suggesting that life-style factors play a significant role in breast cancer BC development. Insulin, which secretion is influenced by life-style factors, might represent the possible etiological linkage between lifestyle characteristics and BC. Insulin might act in the carcinogenetic process through mitogenic effect on breast epithelium. Furthermore, insulin modulates an additional proliferative and hormone-regulating factor which may be involved in the etiology of BC the Insulin-like Growth Factor I IGF-I. The investigators have proposed to test the hypothesis of the linkage between serum insulin and BC in an Italian prospective cohort study conducted to investigate the role of hormones and diet in the etiology of BC the ORDET study.
- Medicine and Medical Research