A Multidisciplinary Approach to Generating Effective Therapeutics for Emerging Hantavirus
Annual rept. 1 May 2000-30 Apr 2001
NEW MEXICO STATE UNIV LAS CRUCES
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The major goals of this project are to purify hantavirus proteins Jonsson for X-ray structure determination Arnold. By defining the three-dimensional structures of the N and RDRP proteins of hantaviruses, our studies will afford a means to model drugs that specifically interfere with important stages of viral replication. Particularly, disrupting one or more functions of the RDRP is expected to result in effective disease treatment with little toxicity to host cells. In addition, our research will yield a high through-put in vitro assay for identification of new antiviral drugs. Together, these studies should lead toward effective therapeutic measures for controlling and treating hantaviral infections.
- Medicine and Medical Research