The Role of the Cell Surface Proteases Meprin A and B in Breast Cancer Progression
PENNSYLVANIA STATE UNIV COLL OF MEDICINE HERSHEY
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Meprins are extracellular proteases that have been implicated in the progression of cancer from a nonmetatstratic to a metastatic phenotype. Current studies have indicated that meprins can cleave the extracellular matrix protein fibronectin, and denatured collagen gelatin in vitro. In addition, overexpression of meprins on cultured breast cancer cells increased their in vitro invasiveness through reconstituted basement membrane Matrigel. This evidence indicates meprins may influence extravasation, intravasation and formation of tumors at secondary sites.
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