Accession Number:

ADA390830

Title:

Sensitive, Selective Fluorescent Probes for the Detection and Identification of Nucleic Acids

Descriptive Note:

Final rept. 1 Apr 1997-3 Mar 2000

Corporate Author:

ROCHESTER UNIV NY DEPT OF CHEMISTRY

Personal Author(s):

Report Date:

2001-03-31

Pagination or Media Count:

7.0

Abstract:

The long-term goals of this project are to develop new strategies for the use of oligonucleotides tagged with multiple fluorescent labels as hybridization probes of specific nucleic acid sequences. First, we have designed and continue to design new classes of fluorescent labels for DNA. Second, we have developed novel modes of interaction between fluorescent labels, leading to color changes on detection of nucleic acids. Finally, we have developed new methods for increasing specificity of nucleic acid recognition.

Subject Categories:

  • Biochemistry
  • Organic Chemistry
  • Optics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE