MHC Genes and Breast Cancer
Annual rept. 15 Aug 1999-14 Aug 2000
MASSACHUSETTS GENERAL HOSPITAL BOSTON
Pagination or Media Count:
Tumors are believed to emerge only when immune surveillance fails. We wished to ascertain whether the failure to inherit putative protective alleles of HLA class II genes is linked to the development of breast cancer. We molecularly typed BLA DPB1, DQB1, DRB1 and DRB3 alleles in 176 Caucasian women diagnosed with early onset breast cancer, and in 215 ethnically matched controls. HLA DQB03032 was identified in 7 of controls but in no patients with early onset breast cancer p 0.0001. HLA DRB 111 alleles were also significantly overrepresented p 0.0001 in controls 16.3 as compared with patients with early onset breast cancer 3.5. HLA DQB03032 and HLA DRBl11 alleles may have a protective role in human breast cancer. The above results are in press and we are currently extending this study in a larger cohort to confirm that these HLA class II alleles are indeed protective and thus determine if future approaches to the therapy of breast cancer should be based on the reintroduction of protective alleles into antigen presenting cells.
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