Accession Number:

ADA390664

Title:

Preparation of a Burkholderia Mallei Vaccine

Descriptive Note:

Final rept. 15 Dec 1997-14 Dec 2000

Corporate Author:

CANADIAN COMMERCIAL CORP OTTAWA (ONTARIO)

Personal Author(s):

Report Date:

2001-01-01

Pagination or Media Count:

57.0

Abstract:

Glanders, caused by Burkholderia mallei, is a significant disease for humans due to the serious nature of the infection. It is recognized that B. mallei is an organism with tremendous infectivity that poses a significant hazard to humans exposed to aerosols containing this organism. Our knowledge of the pathogenesis of disease due to B. mallei is lacking. At present, no effective vaccines are available against this organism, and information on the treatment of this organism with antibiotic therapy is also not available. The basic studies that we are performing on the pathogenesis of disease due to B. mallei are acutely needed, and the information gained from these studies will provide a knowledge base that is required to rationally design new modes of therapy directed against this organism. The long-term objective of our research is to define at a molecular level the pathogenesis of disease due to B. mallei and to develop immunoprotective vaccines against these organisms for use in humans.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE