Psycho-Endocrine-Immune Profile: Implications for Quality of Life in Breast Cancer Patients
Annual rept. 1 Nov 1999-31 Oct 2000
LOYOLA UNIV MAYWOOD IL
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Breast biopsy is an emotional experience that may impair anti-tumor immune responses. This study determined a womans psychological and immune response pre T1 and T2 and post T3 and T4 breast biopsy. Overall, stress, anxiety, and mood disturbance were heightened pre-biopsy. Post-biopsy, stress, anxiety, and mood disturbance diminished but remained increased relative to non-biopsied control women. Natural killer cell activity NKCA was depressed pre- and post-biopsy compared to non-biopsied control women. Women with cancer had greater stress and lower NKCA post-biopsy compared to women with benign results. IL-6 production by peripheral blood mononuclear cells of biopsy patients was increased both pre- and post-biopsy compared to control women. Conversely, IFNgamma and IL-2 were depressed at Tl-T4, while IL-4 and IL-l0 were increased at T2 and T3 and normalized by T4 relative to control women. Thus, breast biopsy produced stress, anxiety, and mood disturbance, which was diminished post-biopsy. Breast biopsy was accompanied by depressed NKCA and altered cytokine production that persisted well beyond the biopsy experience and were more marked in women diagnosed with breast cancer. In conclusion, psychological and immune dysregulation begin early in a womans encounter with breast cancer and may influence cancer control.
- Medicine and Medical Research