The Role of Notch in Regulating Apoptosis in the Mammary Gland
Annual rept. 1 Jun 1999-31 May 2000
MASSACHUSETTS UNIV AMHERST
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Notch4 expression in the mouse mammary gland is associated with mammary gland tumors. Previously we demonstrated that a member of the nuclear hormone receptor family interacts with Notch1. One functional consequence of this interaction is an anti-apoptotic effect in cells expressing activated Notch1. We hypothesized that Notch4, like Notch1, might interact with other members of the nuclear hormone receptor family in mammary gland epithelium and this may prevent the normal apoptotic cell death that occurs during remodeling in the post-lactating breast. The aims in this proposal are designed to test this hypothesis. Results are discussed suggesting that Notch4 regulates progesterone receptor signaling.
- Medicine and Medical Research