A Novel Member of the Insulin-Like Growth Factor Binding Protein Superfamily in Prostate Cancer
Annual rept. 1 Feb 2000-31 Jan 2001
OREGON HEALTH SCIENCES UNIV PORTLAND
Pagination or Media Count:
The insulin-like growth factors IGFs are potent mitogens for normal and cancerous prostatic cells. The IGFs are found complexed to IGF binding proteins IGFBPs which modulate IGF bioactivity, but also may themselves act in an TGF-independent manner. We have recently characterized a series of IGFBP-related proteins IGFBP-rPs which share homology with the IGFBPs in the amino-terminus, bind IGFs with low affinity, and regulate cell growth through both IGF-dependent and IGF-independent actions. This grant is directed at the study of IGFBP-rP2 also known as connective tissue growth factor as a regulator of normal and malignant prostatic growth. The specific aims are to 1 analyze IGFBP-rP2 mRNA and protein expression and distribution in normal and malignant prostatic tissues 2 determine the transcriptional, translational and post-translational regulation of IGFBP-rP2 and 3 determine the mechanisms by which IGFBP-rP2 regulates prostate growth.
- Medicine and Medical Research