Accession Number:

ADA386830

Title:

Interstitial Optical Diagnosis and Treatment of Breast Cancer

Descriptive Note:

Annual rept. 1 Sep 1999-31 Aug 2000

Corporate Author:

UNIVERSITY COLL LONDON (UNITED KINGDOM)

Personal Author(s):

Report Date:

2000-09-01

Pagination or Media Count:

51.0

Abstract:

Spectral analysis of white light reflected from tissue is a rapid, non-invasive, diagnostic technique. We collected paired optical and conventional histologic measurements from 290 sites in breast and axillary nodes and looked for spectral features to identify cancer. Spectral analysis used artificial neural networks ANN, hierarchical cluster analysis HCA and model based analysis MBA. The sensitivity and specificity for detecting cancer in breast tissue or lymph nodes were Breast ANN RCA MBA Sensitivity 69 67 94 Specificity 85 79 92 Nodes ANN RCA MBA Sensitivity 58 91 57 Specificity 93 76 85 Therapy aims for complete ablation of small cancers using MR guided Interstitial Laser Photocoagulation ILP. We have shown that ILP can ablate small cancers and that contrast enhanced MR can detect untreated areas of cancer as small as 2mm. The number of suitable patients for study is small. The main problems are technical rather than biological. Real time imaging of ILP is possible in high field, closed MR scanners 1.5T, where fiber positioning is difficult, but not in low field interventional scanners O.2T. ILP to fibroadenomas confirmed that laser necrosed tissue is resorbed and the treated area heals safely . The latter could become a valuable treatment in its own right.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Optics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE