Therapeutic and Chemopreventive Actions of a Novel Polyamine Analog Against Breast Cancer
Annual rept. 1 Sep 1999-31 Aug 2000
JOHNS HOPKINS UNIV BALTIMORE MD SCHOOLOF MEDICINE
Pagination or Media Count:
The intracellular polyamines, spermidine, spermine, and putrescine, play an important role in the proliferation and death of normal and malignant cells. As a consequence work has focused on development of inhibitors of this metabolic pathway, particularly diethylnorspermine DENSpm. In the first year a phase II trial of DENSpm for women with advanced breast cancer has enrolled nine women. Response analysis is in progress and no excessive toxicity has been observed. Collection of DENSpm- and control-treated breast cancer tissues derived from discarded mastectomy tissues has begun and 23 pairs that are potentially suitable for analysis have been stored collection continues. Proposed testing of DENSpm in animal models has been delayed because of our move to a new building with new animal facilities in the middle of the first year and a current concern about whether the cell line proposed is contaminated in some way. It is expected that they will begin shortly. Proposed chemoprevention studies are expected to begin in the second year as initially stated.
- Anatomy and Physiology
- Medicine and Medical Research