Accession Number:

ADA386800

Title:

FC-Gamma Receptor-Targeted Immunization for Breast Cancer

Descriptive Note:

Annual rept. 15 Apr 1999-14 Apr 2000

Corporate Author:

FOX CHASE CANCER CENTER PHILADELPHIA PA

Personal Author(s):

Report Date:

2000-05-01

Pagination or Media Count:

14.0

Abstract:

The objective of this research project is to test the hypothesis that immune responses to a cancer antigen that is commonly overexpressed in breast cancer can be selectively enhanced and lead to protection against such tumors. This hypothesis of Fcgamma receptor-targeted immunization is being tested through the construction of conjugates or fusion proteins containing the HER2neu antigen and an antibody that targets HER2neu to antigen-presenting cells via Fcgamma receptor IIIA. Appropriate immunoconjugates have been prepared and are undergoing testing in a murine model transgenic for human FcgammaRIII. If the hypothesis is validated in the initial experiments, we will construct recombinant fusion proteins with similar specificities and will determine if the sera of immunized mice possess anti-tumor effects

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE