Accession Number:

ADA386653

Title:

Diet, Genetic Polymorphisms and Breast Cancer in African-Americans

Descriptive Note:

Annual summary rept. 8 Sep 98-7 Sep 99

Corporate Author:

HOWARD UNIV WASHINGTON DC

Personal Author(s):

Report Date:

1999-10-01

Pagination or Media Count:

9.0

Abstract:

The primary goal of this project is to identify non-hormonal dietary risk and genetic susceptibility factors for breast cancer in African-American women. This project initial will assess the role of dietary fat, cholesterol, cooking practices e.g., of fatty foods that would increase heterocyclic amines and polycyclic aromatic hydrocarbons, smoking, and alcohol consumption as risk factors for breast cancer. We will specifically test the hypotheses that these are risk factors mediated by host capacity for metabolism. The study design also will allow the testing of new hypotheses as they emerge. A case-control study of 250 breast cancer incident cases and 250 controls will be conducted on African-American women in Washington, D.C. Genetic variation in apolipoproteins Apo E, Apo A, Apo B, N-acetyl transferase NAT I and NAT 2, Cytochrome P CYPIAl, Glutathione-S-transferase Ml GsTMl, and alcohol dehydrogease ADH2 an5DH3 will be determined. Odds ratios and logistic regression will be used to evaluate the association of genetic polymorphisms and dietary factors as risk factors for breast cancer Also examined will be the effect modification for known breast cancer risk factors by these genetic polymorphisms.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE