Regulation of Cell Cyclin Dependent Kinase Inhibitors in the Prostate Cell by RRR-Alpha-Tocopheryl Succinate
HOWARD UNIV WASHINGTON DC
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Specific Aims Environmental factors including diet play an important role in the initiation and progression of prostate cancer. Our hypothesis was that vitamin E succinate VES inhibits cell cycle progression of prostatic cancer cells and thereby reduces cell proliferation, which may lead to more apoptosis. The aim of the grant was to determine 1 if there is differential regulation of p21 and other cell cyclins in response to VES, and determine if VES will arrest prostate cells at either the G0-01 or G2-M phase of the cell cycle 2 if VES exposure is associated with increased apoptosis in prostate cells, or is there just cytostasis alone.
- Medicine and Medical Research