Accession Number:

ADA386638

Title:

Regulation of Cell Cyclin Dependent Kinase Inhibitors in the Prostate Cell by RRR-Alpha-Tocopheryl Succinate

Descriptive Note:

Final rept.

Corporate Author:

HOWARD UNIV WASHINGTON DC

Personal Author(s):

Report Date:

2000-06-01

Pagination or Media Count:

18.0

Abstract:

Specific Aims Environmental factors including diet play an important role in the initiation and progression of prostate cancer. Our hypothesis was that vitamin E succinate VES inhibits cell cycle progression of prostatic cancer cells and thereby reduces cell proliferation, which may lead to more apoptosis. The aim of the grant was to determine 1 if there is differential regulation of p21 and other cell cyclins in response to VES, and determine if VES will arrest prostate cells at either the G0-01 or G2-M phase of the cell cycle 2 if VES exposure is associated with increased apoptosis in prostate cells, or is there just cytostasis alone.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE