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Breast Cancer Tissue Repository

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Final rept. 1 Sep 1994-31 Aug 1999

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The Breast Tissue Repository at Duke University completed its fourth and final year of funding and was granted a no-cost extension to continue its mission for the additional year from 998-999. This report highlights work performed under this no-cost extension year and constitutes the final report on the grant. This resource was designed to 1 provide freshly frozen tumor tissue from primary and metastatic sites lymph nodes for exploratory research, 2 collect serum and plasma from patients and controls, and 3 collect white blood cells from patients and controls. During the past year, we collected tumor tissue from 65 patients, 119 patients donated pre-operative blood samples, and 5 specimens were collected in a sterile fashion for special studies We provided investigators at Duke and collaborating Centers with more than 100 samples of frozen breast tumors. In each case the quality of the tissue was determined by frozen section analysis and macrodissection done to enhance the fraction of the tissue specimen which contained malignancy. Blood samples were distributed to investigators at Duke and sent to collaborators in other institutions. We have applied for administrative continuation without funding to continue the process of serial blood collection from patients already consented and who have already provided a first blood sample. As a partial indication of the success of this bank, we competed for and received a Planning Grant in Breast Cancer from the NCI in 1994. A SPORE in Breast Cancer was awarded in 1995 and a Cancer Genetics Network grant started in 1998.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

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