Training in Support of a Research Project Entitled Regulation of BRCA1 Function by Physophorylation
Annual rept. 1 Sep 1997-31 Aug 2000
TEXAS UNIV HEALTH SCIENCE CENTER AT SANANTONIO
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Mutations to the BRCAl gene are responsible for nearly 50 of inherited cases of breast cancer. However, the precise mechanism by which BRCAl contributes to the progression of tumor development remains to be elucidated. Recent evidence have suggested that BRCAl is important for cellular DNA damage repair andor DNA damage response pathway REVIEWED IN 1, 2. First, mechanistic studies have shown that BRCAl associates with the DNA repair protein triplex, Mre11Rad5ONBSl to form distinct nuclear foci that correlates to sites of DNA damage in cells treated with genotoxic agents 3. Second, overexpression of BRCAl induces the expression of GADD45 and p21, two DNA-damage responsive genes 4,5. Based on these reports, it has been proposed that absence of functional BRCAl leads to aberrant repair of DNA, which in turn, can lead to genomic instability and ultimately, tumourigenesis.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research