Role of Nf-kB/Rel in the Etiology of Breast Cancer
Annual rept. 1 Feb 1999-31 Jan 2000
BOSTON UNIV MEDICAL CAMPUS MA
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Recent evidence suggests one reason for the rise in breast cancer incidence is increased exposure to and bioaccumulation of enviromental pollutants. Work from the Pis laboratory has demonstrated that human breast tumor cell lines and primary breast tumor tissue constitutively express high levels of functional nuclear NF-KBRel activity, in contrast to untransformed breast epithelial cells or mammary tissue. Experiments are proposed using cell lines in culture, primary tissue and a transgenic mouse model to test the role of nuclear NF- KBRel activity in the etiology of breast cancer. The results of these studies will provide important information on the potential role of NF-kBRel factor overexpression in the etiology of breast disease. Ret factors represent an important link between environmental factors and the increased incidence of breast cancer. The different patterns of Ret factor expression in various tumors suggest the possibility that NF-kBRel factor represents a new class of potential markers for analysis of progression of breast disease. Importantly, since Ret factor activity is sensitive to treatment with a number of anti-oxidants, demonstration that NF-kBRel factors play a role in the etiology of breast cancer would provide a new therapeutic target for the treatment of breast disease.
- Anatomy and Physiology
- Medicine and Medical Research
- Environmental Health and Safety