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Neuroprotection from Brain Injury by Novel Estrogens

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Annual rept. 1 Aug 1999-31 Jul 2000

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The present program of research aims at determining the neuroprotective activity of novel estrogens in both male and female model for brain ischemic damage. We have proposed to achieve 4 technical aims over the course of 3 years. These aims relate to a description of the activity of several estrogens against cerebral damage related to middle cerebral artery occlusion in a rodent model, when the estrogens are administered prior to or following the ischemic event. We also are pursuing our observation that androgen reduction is neuroprotective in male subjects. We will assess during years 2 and 3 of the grant the potential mechanisms of the neuroprotective activity of estrogens and of androgen reduction in these models by determining the extent to which estrogens or androgen reduction reduce oxidative damage associated with stroke and then assess the involvement of signal transduction processes and anti-apoptotic proteins in the neuroprotective activity of estrogens. Collectively, these studies will provide the knowledge needed to determine if estrogen therapy and androgen reduction therapy are useful in protection of the brain tissue from damage related to the activities of U.S. Army male and female personnel.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

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