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Magnetic Resonance Arterial Spin Tagging for Non-Invasive Pharmacokinetic Analysis of Breast Cancer

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Annual rept. 30 Sep 1998-29 Sep 1999

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This research project concerns the development of MRI arterial spin tagging to non-invasively measure breast tissue perfusion. The specific aims are to 1 refine arterial spin tagging pulse sequences, 2 develop automated data analysis software, and 3 compare the technique to first-pass contrast-enhanced MRI and biopsy. The scope of effort is mainly limited to technical developments. However, the project includes a performance comparison with first-pass, contrast-enhanced MRI in 60 patients. During the past year, the spin-tagging pulse sequences have been rewritten for a new, research-only, GE 1 .5T Horizon LX Echospeed CVI MRI system at UC Davis. New image processing software, and software for statistical analysis of spin tagging and contrast enhanced dynamic scans, has been written. Prior software was enhanced for easier use by clinicians. Additional patient studies were not done, due to the loss of the co-investigator on the project, and to the lack of availability of an MRI system that could run the pulse sequences, for several months. As a result, the budget and schedule of the project was officially pushed back approximately six months, into the third year of the project, which was originally designed with very light project activity.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology
  • Optics

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