Non-Human Primate Model for Performance Effects of Ethanol
Final rept. 1991-1995
VERIDIAN ENGINEERING ALEXANDRIA VA
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Twenty adult male rhesus monkeys M. mulatta ingested various doses of ethanol mixed in orange-flavored drink 10 to 20 ethanol by volume. After each dose, 4-5 blood samples were analyzed to determine peak blood alcohol level BAL, so as to estimate a dose-response function for each animal. Then, in different but balanced random orders, the animals received ethanol doses estimated to produce BALs of 0.00, 0.08, 0.12, 0.16, and 0.20. Performance of a well-trained compensatory tracking task, the Primate Equilibrium Platform PEP task, was tested for 2 hr, commencing 30 min after the beginning of ethanol ingestion which was completed in 15 min. BAL was determined at 30 min intervals before, during, and after PEP testing. The significant and dose-related performance decrements induced by ethanol varied in severity from nearly undetectable at the lowest dose to periods of incapacitation in many subjects at the highest dose.
- Stress Physiology