Accession Number:

ADA384378

Title:

Wnt-1 Signaling in Mammary Carcinogenesis

Descriptive Note:

Annual rept. 16 Mar 1999-15 Mar 2000,

Corporate Author:

CHILDREN'S HOSPITAL CORP BOSTON MA

Personal Author(s):

Report Date:

2000-04-01

Pagination or Media Count:

21.0

Abstract:

WNT GENES ENCODE A LARGE FAMILY OF SECRETED SIGNALING MOLECULES ESSENTIAL FOR DEVELOPMENT AND ONCOGENESIS. WNT-1, THE FOUNDING MEMBER OF THE WNT GENE FAMILY, WAS INITIALLY IDENTIFIED AS AN ONCOGENE. Ectopic wnt-1 expression causes mammary tumorigenesis in mice, providing a potential model for human breast cancer. However, the cell surface receptor or receptors that mediates Wnt-1 signaling has not been identified, and the molecular and biochemical nature of the Wnt signaling pathway is not fully understood. In a research supported in part by this Career Development Award, I propose experiments combining molecular techniques and the axis duplication assay in the Xenopus embryo to answer two critical questions 1 What is the receptor mediating Wnt-1 oncogenic function 2 How does the Dishevelled protein, which is an essential Wnt signaling component, transduce Wnt-1 signal Here I provide a progress report on our studies on a potential receptor function of LRP6, a member of the LDL receptor-related protein family, in Wnt signal transduction.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE