Do Soy Isoflavones Provide Protection Against Prostate Cancer Via a Classical Estrogen Receptor-Alpa (ER) Independent Mechanism
Annual rept. 1 Jul 1998-30 Jun 1999
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Male populations, which consume soy foods as a major component of their diet, have reduced incidence of prostate cancer. The anti-sex hormone activity in soy has been proposed, but not proven, to provide protection from prostate cancer. Among the soy isoflavones, genistein and daidzein have been found to be the most effective in suppression of breast cancer growth and in vitro prostate cancer cell proliferation. We are testing the hypothesis that soy isofiavones, specifically genistein and daidzein, will provide protection from development and progression of prostate cancer in mice lacking functional estrogen receptor-alpha protein and containing the PBTag transgene TRAMP mice. We are testing if the phytoestrogens are working through ERalpha andor ERbeta and other non-ERalpha estrogen response proteins. The latency of tumor development, tumor size and number, biochemical markers, and histological features will be determined on selected tumors to characterize the progression from normal prostate to neoplastic and metastatic prostate cancer. Through these innovative experiments, we can establish which soy isoflavones are protective against prostate cancer, and we can establish which estrogen receptor pathways are involved.
- Anatomy and Physiology
- Medicine and Medical Research
- Food, Food Service and Nutrition