Comparison of Novel and Known Neuroprotectants for Treating Exposure to Different Types of Toxins
Annual rept. 16 Aug 1999-15 Aug 2000
CONNECTICUT UNIV STORRS
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Hippocampal slice cultures were used to examine excitotoxic responses to AMPA and the neurotoxin trimethyltin TMT known to cause seizures and hippocampal damage. Relatively short exposure to AMPA and extensive infusion of TMT caused spectrin fragmentation and synaptic deterioration that persisted after a 24-h recovery period. Several avenues of protection were effective at promoting recovery when initiated post-insult. These include anti-inflammatory agents, an anticonvulsant, and modulators of AMPA receptors Ampakines that enhance excitatory communication.
- Medicine and Medical Research