Accession Number:

ADA384358

Title:

Comparison of Novel and Known Neuroprotectants for Treating Exposure to Different Types of Toxins

Descriptive Note:

Annual rept. 16 Aug 1999-15 Aug 2000

Corporate Author:

CONNECTICUT UNIV STORRS

Personal Author(s):

• Bahr, Ben A.

Report Date:

2000-09-01

Pagination or Media Count:

99.0

Abstract:

Hippocampal slice cultures were used to examine excitotoxic responses to AMPA and the neurotoxin trimethyltin TMT known to cause seizures and hippocampal damage. Relatively short exposure to AMPA and extensive infusion of TMT caused spectrin fragmentation and synaptic deterioration that persisted after a 24-h recovery period. Several avenues of protection were effective at promoting recovery when initiated post-insult. These include anti-inflammatory agents, an anticonvulsant, and modulators of AMPA receptors Ampakines that enhance excitatory communication.

Descriptors:

• *NEUROTOXINS
• ANTICONVULSANTS
• ANTIINFLAMMATORY AGENTS
• CNS DEPRESSANTS
• CONVULSIVE DISORDERS
• HIPPOCAMPUS
• METHYL RADICALS
• MODULATORS
• NERVE CELLS
• RECEPTOR SITES(PHYSIOLOGY)

Subject Categories:

• Biochemistry
• Medicine and Medical Research
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE