Role of DIP1, a Novel Id-Like Protein in Breast Cancer
Annual rept. 1 Jul 1999-30 Jun 2000
COLUMBIA UNIV NEW YORK
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We have found that Dip1, a novel 45 Kda nuclear protein recently identified in our laboratory is frequently expressed in human breast cancer. In DNA transfection studies we found that the over expression of this protein in MCF-7 human breast cancer cells markedly inhibits growth. In mechanistic studies we obtained evidence that DIPl inhibits the transcription of specific genes by affecting the process of histone acetylation. Studies are in progress to elucidate the precise molecular mechanisms. The results obtained may suggest new approaches to breast cancer chemoprevention and therapy.
- Anatomy and Physiology
- Medicine and Medical Research