Accession Number:

ADA383956

Title:

Role of DIP1, a Novel Id-Like Protein in Breast Cancer

Descriptive Note:

Annual rept. 1 Jul 1999-30 Jun 2000

Corporate Author:

COLUMBIA UNIV NEW YORK

Personal Author(s):

Report Date:

2000-07-01

Pagination or Media Count:

30.0

Abstract:

We have found that Dip1, a novel 45 Kda nuclear protein recently identified in our laboratory is frequently expressed in human breast cancer. In DNA transfection studies we found that the over expression of this protein in MCF-7 human breast cancer cells markedly inhibits growth. In mechanistic studies we obtained evidence that DIPl inhibits the transcription of specific genes by affecting the process of histone acetylation. Studies are in progress to elucidate the precise molecular mechanisms. The results obtained may suggest new approaches to breast cancer chemoprevention and therapy.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE