How Do Genetic Determinants of Bone Mass Relate to Breast Cancer Risk
Annual rept. 1 Aug 1999-1 Aug 2000
WAYNE STATE UNIV DETROIT MI
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The purpose of this study is to investigate the relationship between breast cancer risk, bone mass, and two polymorphic hormone receptor genes-the Estrogen Receptor ER and the Vitamin D Receptor vDR genes. We will explore a possible functional mechanism in the third and final year to help explain the association between ER variants and breast cancer risk. Our target sample size is 200 new breast cancer cases and 200 controls both African-American and white, ages 40-85. To date, we have recruited 280 cases and controls and expect to reach our target halfway through the third year February 2001. Preliminary results show that age-, weight-, and ethnicity-adjusted bone mineral density in the forearm is higher in the breast cancer cases than controls 0.345 vs 0.332 gsq cm for distal site, 0.796 vs 0.789 gsq cm for the proximal site. The vDR frequencies appear to be different in the cases and controls such that the bb genotype associated with higher bone mass is more prevalent in the cases than in the controls. There are no definitive findings with the ERG polymorphism at this time. In summary, our positive findings thus far support our hypotheses that higher bone mass is found in breast cancer cases compared with controls, and that variations in the vDR gene may contribute to this association.
- Anatomy and Physiology
- Medicine and Medical Research