Accession Number:

ADA383948

Title:

Targeting Breast Cancer with Anti HER2/neu Diabodies

Descriptive Note:

Annual rept. 22 Jun 1998-21 Jun 1999,

Corporate Author:

FOX CHASE CANCER CENTER PHILADELPHIA PA

Personal Author(s):

Report Date:

1999-07-01

Pagination or Media Count:

9.0

Abstract:

The objective of this proposal is to develop new therapeutic reagents for breast cancer. It is our hypothesis that improved diabody-based molecules with affinity for HER2neu can be engineered and will prove to be effective vehicles for the Rff of breast cancer. The first Technical Objective T.O. has focused on optimization of the production of the selected diabody and the identification of the optimal radionuclide and labeling strategy for diabody-based RIT. This T.O. has involved an investigation into the impact on diabody targeting and RIT of a variety of factors likely to be encountered in a clinical setting. These include the degree of antigen density, the route i.v. bolus or continuous infusion and frequency of administration, the presence of disseminated disease, and the effect of antigen expression on normal tissues. These experiments have set the stage for proceeding to the clinical evaluation of diabody- based targeting of breast cancer in our second Technical Objective. The clinical component of this proposal will entail a Phase I radioimmunoimaging and radioimmunoguided surgery trial designed to elicit information on the dosimetry, specificity and tumor penetration properties of radiolabeled C6.5 diabody, and will assess the RIT potential of this molecule.

Subject Categories:

  • Anatomy and Physiology
  • Radiobiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE