Homeostatic & Circadian Regulation of Wakefulness During Jet Lag and Sleep. Sleep Deprivation: Effect of Wake-Promoting Countermeasures
Final technical rept. 1 Jun 1995-31 May 2000
PENNSYLVANIA UNIV PHILADELPHIA BOARD OF TRUSTEES
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The overarching objective of the AFOSR PRET Center for Countermeasures to Jet Lag and Sleep Deprivation was the completion and integration of basic scientific research from three university laboratories for the goal of developing technologies that overcome the performance-impairing problems and risks posed by jet lag and sleep deprivation. Major human research projects on the effects of induced jet lag and sleep deprivation and their mitigation by sustained low-dose caffeine and naps were undertaken at the University of Pennsylvania and Harvard, where investigators also performed work on development of a biomathematical model of the combined circadian and homeostatic regulation of performance and the effects of countermeasures light, naps, caffeine. A parallel set of major research projects undertaken by investigators at Stanford University studied the effects of a range of wake-promoting substances in animal models. Additional ancillary objectives were also addressed at all sites. Center investigators also trained students and professionals in fatigue countermeasure research disseminated discoveries through hundreds of presentations and publications and transitioned knowledge gained through Center research on countermeasures to the Air Force and related DoD, Federal and private environments.
- Anatomy and Physiology
- Stress Physiology