Accession Number:

ADA383763

Title:

The Bactericidal Activity of the Serum of Healthy Beagles

Descriptive Note:

Technical Progress rept.

Corporate Author:

LOVELACE FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH ALBUQUERQUE NM

Personal Author(s):

Report Date:

1964-06-01

Pagination or Media Count:

17.0

Abstract:

A relatively simple method for testing the bactericidal activity of serum from beagles which gave reproducible results was found. Activity was measurable for a strain of Escherichia coli, but not for Pseudomonas aeruginosa, Proteus mirabilis, or Bacillus subtilis. The E. coli bactericidin was inactivated by heat, was not restored by the addition of guinea pig complement, nor augmented by adding complement to the unheated serum. Such serum activity is apparently part of the immune mechanism of beagles and may be important in relation to their ability to resist invasion of the blood stream by intestinal bacteria.

Subject Categories:

  • Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE