Ventilation-Perfusion Alterations after Inhalation Injury in an Ovine Model
ARMY INST OF SURGICAL RESEARCH FORT SAMHOUSTON TX
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Ventilation- perfusion alterations after smoke inhalation injury in an ovine model. J. Appl. PhysioL. 815 A 2250-2259, 1996. To study the pathophysiological mechanism of progressive hypoxemia after smoke inhalation injury, alterations in ventilation-perfusion ratio VAQ were studied in an ovine model by using the multiple inert gas elimination technique. Because ethane was detected in expired gas of some sheep, we replaced ethane with krypton, which was a unique application of the multiple inert gas elimination technique when one of the experimental gases is present in the inspirate. Severity-related changes were studied 24 h after injury in control and mild, moderate, and severe inhalation injury groups.
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