IGF-1, 1,25 (OH)2 Vitamin D, and Prostate Cancer
Annual rept. 1 Oct 1998-30 Sep 1999
HARVARD SCHOOL OF PUBLIC HEALTH BOSTON MA
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High circulating levels of insulin-like growth factor 1 IGF-1 or low levels of 1,25OH2 vitamin D 1,25OH2D are associated with an increased risk of prostate cancer. This project examines whether specific dietary patterns are related to prostate cancer by influencing levels of IGF-1 and 1 ,25OH2D specifically whether high energy and protein intakes increase IGF-1 and high intakes of calcium, phosphorus, and animal protein decrease 1 ,25OH2D levels. The relationships between dietary factors and circulating IGF-1 and 1,25OH2D are being examined using the Massachusetts Male Aging Study, for which dietary data and blood samples have already been collected.
- Medicine and Medical Research