Metallo-Network Polymers: Biomimetic Metal Binding/Recognition Sites
Final rept. 1 Aug 1996-31 Jul 1999
KANSAS UNIV LAWRENCE DEPT OF CHEMISTRY
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New composite materials have been designed and fabricated with funds provided by ONRDESPCoR grant N00014-96-1-1216. Copolymers have been developed from molecular precursors, which dispersed metal complexes throughout highly crosslinked, porous organic hosts. These materials have been applied to problems in gas storagerelease and transport, and sensor technology. They are durable, function in water and organic solvents, and maintain their binding site structures. Materials that reversibly bind O2 and NO have been designed and synthesized. Rapid and reversibly dioxygen binding is observed with dioxygen binding capacities of approximately 160 micro mol O2g polymer. Biomedical applications include artery smooth muscle relaxation under biologically relevant conditions, which is induced by the release of NO from a NO-containing polymer. This NO-releasing material also inhibits platelet formation in an in vitro assay.
- Inorganic Chemistry
- Polymer Chemistry
- Biomedical Instrumentation and Bioengineering