Impact of Breast Cancer Treatments on Gonadal Function and Reproductive Health
Annual rept. 30 Sep 1998-30 Sep 1999
CALIFORNIA UNIV LOS ANGELES
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There is a growing body of epidemiological literature supporting the positive relationship between a womans endogenous lifetime hormone exposure and the risk of breast cancer. Specifically, early menarche and late menopause are associated with increased risk of breast cancer, and this risk is reduced by surgical oophorectomy in the premenopause. Breast cancer adjuvant treatments often lead to premature menopause, and this may be an important factor in the efficacy of these treatments in younger women. However, women who experience premature menopause are at increased risk of earlier cardiovascular disease, as well as premature osteoporosis. Further, numerous epidemiological studies support the benefits of supplemental estrogen therapy in the postmenopause as an effective means of reducing mortality from both cardiovascular disease and osteoporotic fractures. There is uncertainty about how all of these factors play out in breast cancer survivors who have experienced premenopausal disease. Therefore, the primary focus of this cross-sectional study is to examine gonadal function and reproductive health comprehensively in long-term survivors of breast cancer.
- Anatomy and Physiology
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