Insulin and Breast Cancer Risk
Annual rept. 1 Jun 1999-31 May 2000
STATE UNIV OF NEW YORK AT BUFFALO AMHERST
Pagination or Media Count:
There is evidence suggesting that life-style factors play a significant role in breast cancer BC development. Insulin, which secretion is influenced by life-style factors, might represent the possible etiological linkage between lifestyle characteristics and BC. Insulin might act in the carcinogenetic process through mitogenic effect on breast epithelium. Furthermore, insulin modulates an additional proliferative and hormone-regulating factor which may be involved in the etiology of BC the Insulin-like Growth Factor I IGF-I. The investigators have proposed to test the hypothesis of the linkage between serum insulin and BC in an Italian prospective cohort study conducted to investigate the role of hormones and diet in the etiology of BC the ORDET study. 10,788 healthy volunteer women, aged 35-69, residents in Varese province, an area covered by the Lombardy Cancer Registry, were enrolled between June 1987 and June 1992. At the recruitment, blood samples were collected between 800 and 930 A.M., after an overnight fast, and stored at -80 deg C. During the first seven years of follow-up, the cancer registry identified 144 breast cancer cases.
- Medicine and Medical Research